The present research evaluated the effect of different pharmacological combinations, in spraying baths against ticks in cattle, in order to know the most effective treatment, the prevalence of ticks in the area and which are the most common anatomical regions of location of ticks; besides, they identified the species of ticks according to their taxonomic classification and determined the presence of milk trace drugs in animals. With the use of a statistical model (DBCA) with 60 animals in study and a total of 3 treatments and 20 repetitions, besides an entomological study of the collected animals and liquid chromatography of the milk obtained from the animals in study. It was determined that the treatment with the highest efficacy and external antiparasitic action was the pharmacological combination 2 that corresponded to the T3 treatment presenting the highest efficacy against tick infestation. We could catalogue as endemic the presence of ticks of the genus (Boophilus microplus), since we could establish 100% of prevalence, besides, a genus of ticks (Boophilus microplus) was obtained. The anatomical region of preference of the tick Boophilus microplus was established in the members of the rear train due to the great musculature found in this area, besides another area that had great predilection was the abdominal region due to the great irrigation it presents. By means of a chromatographic study, it was determined that no residues of Amitraz, Fipronil, Dichlorvos and Cipermetrine were found in raw milk from the animals submitted to spray baths in the present investigation.