Diabetes is a common and debilitating disease of humans that can cause serious problems for the organs. One of these problems is chronic and refractory wounds that usually occur in the soles of the feet of these patients. This complication is also called Diabetic foot. This study aims to see whether there is an effect of plasma therapy on the wound healing phase of diabetic ulcers in patients with diabetes mellitus at van hospital . This research is quassy experiment with samples in this study amounted to 20 patients diabetes mellitus at van City hospital. This research was conducted from 04 until 18 October 2020. Sampling by total sampling method. The analysis used paired t-test (dependent). The result of this research is the age of patient of diabetes mellitus patient at van cıty hospital most of the aged between 56-65 years as many as 12 respondents (60,0%) and gender of patient of diabetes mellitus mostly female are 11 respondent (55,0%) . The result of paired t test is obtained p-value 0.000 <α = 0,05. This shows that there is influence of plasma therapy to phase wound healing diabetic ulcer in patient of diabetes mellitus at van cıty hospıtal . The results of this study can provide benefits for the community, especially reponden that as an input that plasma can serve as a new treatment alternative in addressing the problems of diabetic wounds with modern wound care so convincing to the public that diabetic wounds can be cured.