Background: Solitary thyroid nodule is one of the most frequent presentations of thyroid disorder. This study aimed to evaluate the Socio-clinical Characteristics of Solitary Nodule of Thyroid at Krishna Rajendra Hospital, Mysore. Methods: This prospective study included 55 patients, who were clinically diagnosed as solitary nodule of thyroid in the Department of Surgery at K R Hospital attached to MMC & RI, Mysore during the period of 18 months from January 2011 to July 2012. All patients were subjected to thyroid profile, USG & FNAC examination