Introduction: Dengue is one of the major re-emerging viral infections. In recent years, dengue has become a major global public health concern. In small subset of patients, there is life threatening condition with severe cytopenias and significant systemic response. The presence of macropage activation in dengue fever is well reported and could be one possible reason for mortality and morbidity. Dengue being an infective condition, a modest rise in ferritin levels and CRP are expected in dengue fever as well. In dengue fever sr. ferritin is disproportionately raised compared to any bacterial or viral infection