Background: Pemphigus vulgaris is the most frequent and most severe form of pemphigus, occurring universally, usually between 40 and 60 years of age. The present study was conducted to assess the prevalence of Pemphigus Vulgaris in a known population. Materials & Methods: The present study was conducted over a period of 6 months in the Department of Dermatology, L. N. Medical College & Research Centre, Bhopal, Madhya Pradesh (India) to assess the prevalence of Pemphigus Vulgaris in a known population. All the participating patients were asked to fill up a simple performa. The P-values of 0.05 or less were considered to indicate statistical significance. The statistical analysis was conducted using SPSS version 20 (IBM Corp., Armonk, NY, USA)