Aim: To analyse the post-operative wound complications in patients getting neoadjuvant chemotherapy in respect to those patients who underwent surgery without any neoadjuvant chemotherapy. Material and method: The present prospective observational study was conducted in GMCH AMRITSAR Punjab.It consisted of 50 female patients admitted with breast carcinomadivided into group of 25 each, one group that received neoadjuvant chemotherapy and the other group which underwent surgery first. Results: The mean age of the patients was 50.16±11.57 years. no significant difference was observed in age, wound complications, healing time between the two groups. Flap necrosis was seen in 4% cases and 12% cases in group 1(primary surgery) and 2(NACT) respectively. Seroma was seen in 16% and 8% cases in group 1 and 2 respectively. 12% cases of group 1 and 20% cases of group 2 presented with wound infection. Patients with DM presented with more complication in both the groups. The difference between both the groups was significant which shows that diabetic patient without NACT have more risk of developing wound complications than with NACT.No significant difference was observed between the mean of healing time in both the groups . Conclusion:In conclusion, our study revealed that a factor, like diabetes mellitus was associated with an increased risk of wound complications for patients undergoing mastectomy. However, neoadjuvant chemotherapy was not associated with an increased risk of wound complications.