Background: The transmission of orthodontic forces through the stressed tissue matrix onto the local cells within the periodontal ligament and alveolar bone, stimulate the cells to release proinflammatory, angiogenic and osteogenic agents that activates the process of periodontal ligament and alveolar bone remodelling. Studies have suggested that orthodontic therapy when not fully controlled, may influence the process of inflammation and the destruction of periodontium leading to increased loss of attachment.