Objective: The study was aimed to assess knowledge, attitude and practices of retail pharmacists towards Pharmacovigilance (PV) and ADR reporting in Thiruvallur district, Tamilnadu towards adverse drug reactions (ADR). Methods: In this study we had selected community pharmacists as the study population. Registered Pharmacists working at retail Pharmacies were asked to complete a paper-based questionnaire which included 10 questions related to knowledge and 8 questions related to attitude and practice towards adverse drug reaction (ADR). Results: The total of 69 participants provided their response. The demographic details are tabulated in table.1. The knowledge of the participants regarding the Pharmacovigilance was assessed by asking 10 questions. A score of 1 was given for correct answer and 0 score for wrong answer. The highest score obtained was 9 and the lowest score was 0.The percentage of knowledge of the participants (Retail Pharmacists) about the Pharmacovigilance was only 26%. Conclusion: The result showed the retail Pharmacist had a poor knowledge and practice towards PV at the same time they showed a good attitude towards adverse drug reactions. Our study also suggests that more awareness is needed to improve reporting.