Abstract In Ethiopia, onion is the most habitually cultivated vegetable and the next widely cultivated vegetable is Garlic(Allium sativum L.). It is mainly produced for the purpose of medical and nutritional treatments. Soil-borne fungus(Sclerotium cepivorum Berk.) spreads the white rot. It is very dangerous for garlic production and it totally destroys its production rate. Therefore, this research work mainly focuses to examine the effectiveness of fungicides involved in garlic production and improve the various varieties of garlic production in terms of its cultivation and also safeguard from the white-rot disease in west Shewa disease in West Shewa, Ethiopia. This field demonstration was done during the 2018/2019 cropping season at Ambo University Gudar Campus. It is arranged on the basis of 5 x 3 factorial treatment along with untreated control plots in an randomized complete block design with 3 replications and also combining five varieties namely Holeta, Chefe, Tseday (G-493), kuriftu and local cultiver (as check) and two fungicides namely Pro-seed plus 63 WS and Tebuconazole (Natura 250 EW). Before planting the Garlic cloves its was treated using fungicies. An entire of fifteen treatments had been examined per replication. On the basis of reducing disease epidemics and intensifying the garlic production over untreated plots, two fungicides had been very effective. These fungicide treated plots proseed plus was major effective while reducing the disease epidemics and also provide better production benefits. When compared to untreated plots, pro-seed plus treated plots reduces initial, final incidence and soverity as 57.12%, 35% and 64.25% and also recorded successfully. Then the results showed sufficiently great production rate and it was recorded from Tseday varieties treated with Pro-seed plus 63 WS (3.047t ha-1 ) followed by Kuriftu varieties treated with the same fungicides (2.973t ha-1 ) compared to the untreated control plots. Significantly,higher net profit was obtained from Pro-seed plus 63WS treated varieties compared to Tebuconazole and untreated control plots. Among various garlic varieties, Tseday (G-493) was the favourable in terms of reducing the disease epidemics also provide better production rate in terms of cultivation. However, for wider applications or recommendation of these management options, further research should be conducted with the same varieties combinations with fungicides against white rot under multi locations and in different seasons.