the rate of synthesis of one or more globin chains. Endocrine abnormalities in thalassemia major are common alarmingobstacles which require prompt management. Objective: To know the prevalence and pattern of endocrinopathies among thalassemicmale children (N=85) within 6months to 18 years of age attending thalassemia day care centre in department of paediatrics GMC, Jammu. Results: All of the patients (98.8%) had thalassemia major; minor type of thalassemia was present in one patient only. Hypothyroidism and hyperthyroidism were present in 7% and 2% patients, respectively. Majority (69.41%)of the patients had lower Vitamin B12 level. Diabetes mellitus was absent. All patients had reduced haemoglobin level. Testosterone level was also normal. Among male children ≤ 10 years, only megaloblastic anaemia was present in 72.09% patients. In male children >10 years age, megaloblasticanaemia and Hypothyroidism were noted