Background: Acute abdominal pain is among the three most common symptoms in patients coming to emergency departments or being admitted to hospitals. Computed tomography is more sensitive and accurate at detecting abnormalities than plain radiography because of its cross sectional nature. Hence; the present study was undertaken for evaluating efficacy of computed tomography in diagnosis of acute abdomen. Materials & methods: The present study was conducted with the target of analysing the effectiveness of computed tomography in diagnosis of acute abdomen. Continuous monitoring of the hemodynamic vitals was done during the contrast injection procedure. Evaluation of 20 subjects was done who were referred to our Department with clinical presentation of acute abdomen were enrolled. US of the abdomen were done in all the patients. Clinical and demographic details of all the patients were obtained. A predesigned Performa was made for compiling the radio-imaging findings. The statistical analysis of the data was done using SPSS version 11.0 for windows. Results: Sensitivity and specificity of CT in diagnosing Mesenteric ischemia, Gut malrotation, gut perforation and gall bladder perforation was 100 percent each. In diagnosing appendicitis, sensitivity and specificity was 90 percent each while in diagnosing pyelonephritis, sensitivity and specificity was 80 percent and 90 percent respectively. Conclusion: For establishing the diagnoses of acute abdominal pain patients, MDCT is an effective imaging modality