INTRODUCTION Breast cancer is the most common cancer among the woman and is on rise. Surgery is one of main stays of treatment of breast cancer. Pectoral nerve block type 2 is an extension of type 1 that requires additional injection of local anaesthetic between pectoralis minor and serratus anterior muscle. MATERIALS AND METHODS This Prospective Randomized Controlled study wad conducted between January and June 2020. 60 Patients undergoing Mastectomy under General Anaesthesia with an ASA of I or II were taken. In Group P, 0.4ml/kg of the drug is deposited above the serratus anterior muscle. OBSERVATIONS AND RESULTS The difference in baseline mean systolic and diastolic blood pressures of two groups was statistically not significant. Time of first rescue analgesia is significantly higher in group P (5.89±2.25 hours) than group C (2.08±0.7 hours). Pains scores are significantly higher in group C compared to group P at all times after surgery from 2 to 18 hours postoperatively. The patients who received block used significantly less morphine than the control population. None of the patients in group P experienced block related complications.