Abstract Background - The diabetes is a carbohydrate metabolic disorder which is caused either due to the inadequate production or usage of insulin. In the modern world, the diabetes is often attributed to the changes in life style or life style related disorder. According to ‘Ayurveda’ the diabetes mellitus-II (DM-II) can be compared with Madhumeha. The symptoms of madhumeha which are highly similar to diabetes such as, frequent urination, excessive thirst, hunger, constipation, etc. For diabetes many treatment options are available amongst which, the Ayurveda can be one of the most promising alternative therapy. In Ayurveda, the Panchkarma, which is a purification process for the removal of toxins. In the Panchkarma, the virechana(laxative) is one of the five process involved in flushing out the toxins from the body. In the present study, Argwadha kwatha (decoction)obtained from the plant Cassia fistulais selected as a laxative for the effective treatment of madhumeha, owing to its multiple beneficiary effects. Methodology- It is an open label, Randomized comparative clinical trial. Patients with high BSL level than normal will be enrolled with two groups each containing 75 patients. Intervention group trial with Argwadha kwatha Nitya Virechan 60 ml in the morning, And the second group trial with the Nishakathkadi kwatha 20 ml B.D.for 21 days with the 3 follow up. Assessment of result will depend on the BSL level and associated symptoms. Expected Results- the final outcome will show the lowering of BSL level in the patient of Madhumeha. It is the evidence-based trial for the virechana procedure and relief the symptoms in the patient of madhumeha.