Background: Chronic urticaria (CU) is one of the important challenges faced by dermatologists. Chronic autoimmune urticaria (CAU, 45%) and chronic idiopathic urticaria (CIU, 55%), are the 2 main subtypes of CU, with a combined incidence of 0.5% in the general population. Patients with chronic urticaria who frequently exhibit histamine-releasing autoantibodies and who frequently experience wheals and flares in response to intradermal testing with their sera are referred to as having autoimmune urticaria. The current study aimed to evaluate the efficacy of Autologous Whole Blood Therapy, in Autologous Serum Skin Test (ASST) positive and ASST negative Chronic Idiopathic Urticaria (CIU) patients.