Background: Pulmonary rehabilitation is an educational and exercise program to enhance awareness about the client’s lungs and associated lung diseases. The client learns to achieve exercise with less shortness of breath. Aim: The current study aimed to evaluate the effectiveness of a structured teaching program on knowledge regarding pulmonary rehabilitation among patients with chronic obstructive pulmonary disease. Method: A quantitative research approach was used with pre-experimental with one group pre-test post-test design was adopted to assess the effectiveness of a structured teaching program on knowledge regarding pulmonary rehabilitation among patients with chronic obstructive pulmonary disease. A total of 50 patients suffering from chronic obstructive pulmonary disease were selected as study participants through a non-probability purposive sampling technique from selected hospitals. The self-structured knowledge questionnaire was used for data collection. The data were analyzed using descriptive and inferential statistics. Result: The finding of the study indicated that the mean pre-test score of knowledge regarding pulmonary rehabilitation was 14.7 and the post-test mean score was 20.1 respectively. Enhancement was computed by using a paired ‘t’ test at 0.05 level of significance and it was found to be 5.4, indicating that there is a significant improvement in the knowledge of pulmonary rehabilitation among Chronic Obstructive Pulmonary Disease (COPD) patients. Conclusion: The study concluded that the structured teaching program was effective in terms of gaining knowledge of COPD patients regarding pulmonary rehabilitation