Background and objective - Seizures are common disorders found all over the world 16 and are encountered frequently during medical practice in variety of settings. 17 Etiological spectrum of acute symptomatic seizures in developing countries is different 18 from developed countries. So this study was done to know the various etiologies of new 19 onset seizures in adults in this region. 20 Methods - Consecutive 100 Cases of new onset seizures from the hospital attached to 21 Vinayaka Mission’s Medical College, Karaikal, were included in the study. The etiology 22 was determined by neuro imaging and appropriate investigations including 23 cerebrospinal fluid examination. 24 Results - Of 100 patients 89% were acute symptomatic seizures 40% of SE were caused 25 by neuro infections. Neuroinfection was the leading cause of seizure, which accounted 26 for 34%, followed by Cerebrovascular accidents (29%) and metabolic (9%). Neuro 27 cysticercosis is most common cause in neuroinfection (35%), followed by meningitis 28 (29%) and cerebral malaria (17%). 8% of seizures were because of CNS Tuberculosis. 29 55% of the CVA were due stroke and 34% due to CVT. 14% of seizures were pregnancy 30 related. In patients with cerebrovascular diseases, aged under 40 years, cerebral venous 31 thrombosis accounted for79%.