Aim: Estimation of Anti-Arthritic Activity of sustained released tablet of Trapa Bispinosa , Cassia Uniflora , Cissus Quadrangularis and Bosevilla Serrata plants against Freund’s complete adjuvant induced arthritis by using animal models. Materials and Methods: Trapa Bispinosa , Cassia Uniflora , Cissus Quadrangularis and Bosevilla Serrata are well known plants available throughout India and they are commonly used for the treatment of various diseases including arthritis. The polyherbal sustained released tablet contains the ethanol extracts of Trapa Bispinosa , Cassia Uniflora , Cissus Quadrangularis and Bosevilla Serrata . The quality of the finished sustained released tablet was evaluated as per the World Health Organization’s guidelines for the quality control of herbal materials. Arthritis was induced in female Wistar rats using Freund’s complete adjuvant (FCA), and the antiarthritic effect of sustained released tablet was studied at doses of 200 and 400 mg/kg. The effects were compared with those of Diclofenac (20 mg/kg). At the end of the study, blood samples were collected for biochemical and hematological analysis. The radiological examination was carried out before terminating the study. Results: Sustained Released Tablet (TCBC) showed significant antiarthritic activity at 100 and 200 mg/kg, respectively, and this effect was comparable with that of Diclofenac (20 mg/kg). The antiarthritic activity of Sustained Released Tablet is supported by hematological and histopathological analysis.