Introduction: Tranexamic acid (TXA) is a lysine analog that exhibits an anti-fibrinolytic effect by directly preventing the activation of plasminogen as well as inhibiting activated plasmin from degrading fibrin clots. Objectives: The objective of the study is to know the effect of Tranexamic acid in reducing intraoperative and postoperative blood loss in patients undergoing lower limb orthopaedic surgeries and to study the effect of drug on perioperative hemodynamic. Materials and Methods: A prospective randomised control study was done in Basaveshwara Medical College and Hospital, Chitradurga to know the effect of Tranexamic acid in reducing intraoperative and postoperative blood loss in patients undergoing lower limb orthopaedic surgeries. Results: Who received tranexamic acid had roughly 170ml lesser intra-operative blood loss than the control subjects and this difference was statistically significant (p<0.05). Conclusion: Perioperative blood loss and the need for transfusion in major orthopedic surgeries can be effectively reduced by using Tranexamic acid.