Introduction- Performing laparoscopic cholecystectomy is not always an easy task. Surgeons do face difficulties while performing laparoscopic procedures. To overcome the challenges faced by the surgeons and minimize the intraoperative and post-operative complications several technological innovations and advancements in the technique and procedure of laparoscopic cholecystectomy have taken place since its emergence. Methodology- The present prospective observational study included 80 patients. As per SNOSE method, they were further divided into GROUP-I (n=40): Patients who underwent three-port laparoscopic cholecystectomy and GROUP-II (n=40): Patients who underwent fourport laparoscopic cholecystectomy. The intra and post-operative parameters were recorded and compared. Results- Amongst the total 80 patients, the mean age was 45.79±13.97 years. In both the groups, the majority of patients were female. Adhesions were the most common complication seen intraoperatively. Infection at the port site was seen in 2 (5%) of Group-I and 3 (7.5%) of Group-II patients. None of the patients had VAS score >5 after 24 hours in either of the two groups. These clinical findings were comparable in both groups and showed no significant differences. Conclusion- Both three-port and four-port laparoscopic cholecystectomy were shown to be safe and technically adaptive, with few serious problems. The surgeon should make the decision to do a three-port or four-port procedure should make the decision to do a three-port or four-port procedure, as neither appears to impact the surgical course or outcome