Aim: Purpose of our research was to assess the efficacy of cannabinoids in oral care products in reducing bacterial content inside the mouth. Methodology: Dental plaques of 30 healthy adults were collected using paro-toothpick sticks and spread on three Petri dishes (A, B and C) containing cannabinoids containing toothpaste, oral B and Colgate respectively. The Petri dishes were sealed and incubated at 37°C for twenty-four hours, followed by counting the amount of colonies using colony counter. Results: By evaluating the colony count of the dental bacteria isolated from six groups, it absolutely was found that cannabinoids were simpler in reducing the bacterial colony count in dental plaques as compared to the well-established synthetic oral care products like Oral B and Colgate. Conclusion: Cannabinoids have the potential to be used as an efficient antibacterial agent against dental plaque-associated bacteria. Moreover, it provides a safer alternative for synthetic antibiotics to reduce the event of drug resistance.