Proximal humerus fractures are one of the commonest fractures occurring in the skeleton. They account for approximately 4 – 5% of all fracture. Incidence of fracture is more common in elderly because of decreased bone density. But it can occur in younger age group following high velocity trauma. Three- & four-part fractures represent 13 to 16 % of proximal humeral fractures. Treatment options for these displaced fractures include open reduction and fixation. Neer recommended open reduction and internal fixation for displaced two and three parts fractures. Most of the poor results following open reduction and internal fixation of three-part fracture are due to imperfect technique. Objective: To evaluate the incidence of complication that occurs with locking compression plate in proximal humerus fractures. Methodology: Total 40 prospective samples included in this observational study. Patients undergone Open reduction internal fixation with locking Compression plate for the sustained fracture under general anesthesia, with inclusion criteria of Two-part, three-part, four-part proximal humeral fractures, Acute fracture, Age above21 and Patient fit for surgery selected admitted in Mahathma Gandhi Memorial Hospital attached to Kakatiya Medical College, Warangal. Results: The Neer’s scoring system of the severity of Pain, Function, Range of Movement, Anatomy, was done to determine the end results. The end results of 40patientsof proximal humerus fractures which were surgically treated with locking compression plate. In our case study 20% case had excellent results and 60% had satisfactory result 20% had unsatisfactory results and there was no case of failure. Conclusion: In conclusion locking compression plate is mechanically and biologically an advantageous implant in proximal humeral fractures particularly in comminuted fractures and in osteoporotic bones in elderly patients, thus allowing early mobilization.