Abstract: Introduction and goal: Similar to all the other operation, rhinoplasty is not devoid of side effects. Edema and ecchymosis are two common side effects of rhinoplasty and almost all the patients who undergo this operation experience them to a certain degree. Post-rhinoplasty ecchymosis can be mild or severe and can last for weeks to months. Non-steroidal anti-inflammatory drugs (NSAIDs) namely aspirin are able to control and alleviate tissue inflammation. Compared to common corticosteroid medicines, NSAIDs cause far fewer side effects. In the present study, we aimed to assess the effects of aspirin on post–rhinoplasty edema and ecchymosis. Materials and methods: In this study all rhinoplasty candidate patients who were referred to Khatam-Al-Anbia hospital during 2016 and were willing to participate and also met the entrance criterion were studied. Two four-degree quality scales for edema and ecchymosis of each eyelid were used and the data were entered into a prepared checklist. Finally, SPSS ver. 22 software was used for data analysis. Results: Average age of the study population was 27.22±7.98. Post-rhinoplasty edema on seventh post-operative day was (+1) for both studied groups. Furthermore, no significant relationship was found between the second and third post-operative days edemas in both groups. A significant relationship was found between drug therapy and ecchymosis on third (P=0.04) and seventh postoperative days (P=0.023). The least recorded ecchymosis belonged to the control group. The treatment group suffered from more severe ecchymosis. Discussion and conclusion: No significant relationship was found between baby aspirin therapy and severity of edema. In addition, on two cases significant relationships were found between tissue ecchymosis and aspirin therapy, and compared to the control group, the treatment group suffered from more severe ecchymosis.