A pre experimental research design was adopted to evaluate the effectiveness of video assisted teaching programe on knowledge regarding needle stick injury among nursing staffs. Thirty nursing staffs were selected through convenient sampling technique. The Mean knowledge score percentage of pretest was 13-6 (45.3%).The mean knowledge score percentage of post test was 25-73 (85-7%) (p<0.5) was found except age and gender. The VATP on knowledge regarding needle stick injury among staff nurses in selected Hospital at kumbakonam.