Osteoarthritis (OA) is a degenerative disease that affects the weight bearing joints and prevents individuals from participating in activities of daily living and work. Osteoarthritis of the knee causes significant pain along with deterioration in function and mobility, with a higher prevalence in athletes and the elderly (65 years). Knee replacement in its various forms is the most common surgical treatment for osteoarthritis, and the number of knee replacements performed each year has increased in parallel with the increasing incidence of OA. The goal of this systematic review is to establish whether physiotherapy interventions have specific efficacy in the management of TKA, based on published studies. PEDro, Science Direct, PubMed, EBSCO host and Cochrane Library databases were searched from inception to 2nd March 2022. The study uses clinical or controlled trials in which some form of physiotherapy treatment was used to treat TKA. 10 studies were included in this review. One virtual reality-based rehabilitation was investigated, in 5 studies a combination of various exercises was investigated, in 2 studies cryotherapy, CPM & MI training was investigated respectively & one study was on mid vastus technique & Para patellar approach was investigated. Despite its present popularity and widespread use, the research on the use of Active assisted cycle ergometry, virtual reality-based rehabilitation, and specialised hipstrengthening exercises for total knee arthroplasty has inconsistencies. While the quality of evidence for acupuncture with low-level laser therapy and motor imagery training is moderate, the degree of evidence for core stability exercises, isometric quadriceps workouts with auditory and visual feedback varies from moderate to high in quality.