Objective: The present study aimed to investigate The Efficacy of Cognitive-Behavioral Group Therapy on depression, anxiety, and Pain Coping Strategies in women with breast cancer. Methods: The present study is a semi-experimental research wth a pretest-posttest With the control group. For this purpose, 50 people Of women with breast cancer were admitted to the Medical university hospitals of Tehran method Purposive sampling was Selected Randomly in two experimental and control groups were replaced. The experimental group underwent group therapy for 10 sessions of 1.5 hours per week after fully explaining the research and expressing their consent on how to do the work. Demographic statistics, descriptive statistics (mean and standard deviation), and inferential statistics (analysis of covariance (ANCOVA)) were used to perform statistical calculations and data analysis (SPSS 25)