Introduction: Medical education involves pre-clinical and clinical teaching to build a strong knowledge foundation and clinical experience for the medical students. COVID-19 pandemic has imposed challenges for medical education facilities, with the need to shift from tradition class room teaching to E-learning modality. This paradigm shift could generate changes in students’ perception of this way of teaching and their perception might be different from the one found in studies previous to the pandemic. Aim: 1. To assess effectiveness of E-learning classes as compared to conventional classroom teaching-learning method. 2. To assess perceptions of medical students on the role of E-learning in facilitating medical education during COVID-19 pandemic. 3. To evaluate knowledge of electronic gadgets used during E-learning activities. Materials and Methods: This online study was conducted on 1st year MBBS students (total of 101 students), who have already completed online classes from March 2021 to July 2021. A set of self-designed questionnaire was given to assess the effectiveness of learning through online classes and their understanding with satisfaction level on various parameters. Results: In our study, 61.39% of students reported that E-learning was good decision during lockdown. 63.38% of students preferred live lectures as compared to recorded one. 52.48% reported stress during pandemic. Most of the students (81.19%) increased screen time more than 4 hours during pandemic. In terms of examination, 49.50% of students were in favour of class room exam. Very few students (11.88%) of students reported technophobia. 49.50% of students reported internet error while 52.48% of students reported surrounding disturbances while attending E-learning classes. Conclusion: In case of emergencies like pandemic, online teaching could be one of the good option to continue medical education but it cannot replace traditional method of teaching and learning activities.