The goal of the random group experimental research was to figure out the impact of yoga therapy on the peak expiratory flow rate (PEFR) of asthmatic adult women and stress. For the purposes of the study, 30 adult asthmatic women were randomly selected using the Chennai random group sampling method between the ages of 45 and 55 and were divided into two groups, A and B, each with 15 subjects. It was speculated that substantial discrepancies within the control group on selected physiological and psychological variables among asthmatic adult women would occur due to Yoga Therapy. The pre-test on the chosen physiological variable such as Peak Expiratory Flow Rate (PEFR) and psychological variable such as Stress before the start of the training program was conducted for both groups (A and B).Yoga Therapy was given to Group A; Group B (Control Group) received no specific treatment, but were in active rest after the trial duration of eight weeks, all groups were retested on the selected dependent variables. The dependent variables tested were measured and compared using the Study of Co-variance (ANCOVA) approach to figure out the essential variations between the classes. The importance test has been set at a confidence level of 0.05. There was a major increase in the peak expiratory flow rate (PEFR) and depression after eight weeks of yoga therapy. Group A remained significantly relevant relative to Group B at the conclusion of the intervention; it is concluded that yoga therapy had a significant impact among asthmatic adult women on physiological and psychological variables. Yoga therapy is therefore useful in increasing the Peak Expiratory Flow Rate (PEFR) and overcoming stress for asthmatic adult women.