Introduction: A bone fracture is a complete or incomplete discontinuity of bone caused by a direct or indirect force. Irrespective of the reason, type, severity, the fracture will badly affect the regular activities of an individual. Upon studies it has been found that the levels of serum calcium, vitamin-D and parathyroid hormone are related to better fracture healing. The present study is focused on effect of supplementation of calcium, PTH and vitamin-D on the duration of bone fracture healing in individuals with those who are not under any supplementation Materials & Methods: Among the two groups, one group is supplemented with calcium, PTH and vitamin-D whereas another group patients have not received any supplementation. The results were averaged for each parameter subgroups separately for Diabetics & Non-diabetics. Statistical analysis was done using IBM SPSS. Results: It is observed that the mean levels of vitamin-D are higher in the supplementation group. Similarly, the levels of calcium and PTH were also found to be higher in the supplementation group. Discussion: In the present study, the correlation between the levels of serum calcium, PTH, vitamin D are highly significant. This signifies the probability of correlation of bone fracture healing with the levels of calcium, PTH and vitamin-D of the individuals. Studies have shown that vitamin D affects bone healing through action on inflammatory cells, cytokines, growth factors, osteoblasts, osteoclasts, and the mineralization process; however, this effect is considered insufficient to achieve complete repair. The effect of calcium with vitamin D supplementation on fracture healing might require higher doses of vitamin D alone if used. This dose–response concept is supported by studies indicating that low levels supplementation vitamin D has a similar effect when given in combination with calcium and PTH.