Chronic blood transfusion therapy plays a crucial role in the management of various haematological disorders, such as thalassemia, sickle cell disease, and aplastic anaemia. However, repeated blood transfusions can lead to iron overload and subsequent complications, including hemochromatosis. This research aimed to test a screening protocol to identify chronic blood transfusion-related complications and prevent end-stage morbidities, specifically focusing on iron overload and its associated effects. The study will be conducted in Chhattisgarh, considering its high prevalence of blood disorders and the need for optimised transfusion practices.