Background: Based on well-known properties of propofol over last few years this study was undertaken to evaluate whether priming principle applied for the induction dose of propofol would affect the total induction dose requirement and reduce the associated side effects. Methods: The prospective randomized study was undertaken in 100 patients allocated randomly by envelop method, between 18-55 years of age of either gender belonging to ASA class I and II scheduled for elective surgeries under general anaesthesia. In group I Inj. fentanyl 2 µg/ kg administered over a period of 30 seconds intravenously and then induced with the calculated dose of Inj. Propofol 2mg/kg until the loss of eyelash reflex. In group II, 30 % of the total calculated dose of Inj. propofol 2mg/kg 30 seconds after the administration of Inj. Fentanyl 2µg/kg over 30 seconds, which will be followed by the administration remaining calculated dose till the loss of eyelash reflex. Statistical analysis of the demographic data was done using chi-square test. Comparison between the groups for the induction dose and haemodynamic parameters was done using student ‘t’ test. Results: The average induction dose required was 1.53mg/kg with a mean reduction of 23.89%in the induction dose requirement of propofol was observed in the study group. The haemodynamic parameters were better in study group II compared to the control group I. Conclusion: Based on study result we recommend application of ‘priming principle’ for induction dose of propofol.