ABSTRACT: Purpose - To analyses the influence of physical environment and prisoner's behavior by the implementation of control programs on the incidence of TB in Makassar City. Methods - Samples in this study were 90 people who were taken based on people having symptoms of pulmonary tuberculosis which included age, sex, level of education, occupation, and length of stay in prison, humidity, water temperature, room lighting, occupancy density, discharge behavior. Sputum / spit carelessly, smoking habits, cough / sneezing ethics, room contact with friends and implementation of control programs. Results - The incidence of pulmonary TB ie from 90 respondents who suspected there were 41 respondents (45.6%). Variables that are significantly related to TB incidence are the discard phlegm on a reckless place variable, p = 0.008 (p <0.05). Discard phlegm on a reckless place against respondents affected by tuberculosis were 29 people (29%). Variable cough / sneezing ethics obtained p = 0.001 (p <0.05). More respondents were found when cough / sneezing was performed correctly on respondents who did not have tuberculosis in the amount of 25 people (52.1%). Variabel room contact with friends, p = 0.002 (p <0.05). Respondents of room contact with friends were bad for respondents who experienced tuberculosis, namely by 34 people (57.6%). Conclusion - Discard phlegm on a reckless place, cough / sneezing ethics, room contact with friends are significantly related to TB incidence in Makassar City.