Background: Propofol is a popular anaesthetic agent used for induction of general anaesthesia. However, it causes cardio-respiratory depression in vulnerable patients. Materials and Methods: This prospective, randomized and controlled trial was conducted on 60 patients admitted for elective neurosurgical procedure after ethical clearance from Institutional Ethics Committee. After written informed consent, the patients were randomly allocated to two groups, I and II of 30 each. Group I received Inj. midazolam 0.02 mg/kg as premedication five minutes before induction with propofol infusion. Group II received only propofol infusion for induction of general anaesthesia. Total dose of propofol required for induction of anaesthesia was noted. Haemodynamic parameters were noted from baseline till 08 minutes post laryngoscopy and intubation. Results: Samples in both the groups were comparable with respect to age, weight and gender. On comparison with the standard bolus dose of propofol (2mg/kg) for induction, reduction in the doses of propofol in Group I and Group II were 0.7 mg/kg and 0.3 mg/kg respectively. The reduction in the dose of propofol in Group I as compared to Group II was 0.4 mg/kg i.e. 20%. This difference was statistically significant (P<0.001). No statistically significant difference in the haemodynamic parameters between the two groups was observed (p>0.05). Conclusion: Propofol infusion after midazolam premedication reduces the dose of propofol for induction of general anaesthesia and confers haemodynamic stability