Objective: Investigate high tone therapy effect on neurophysiological measures and function outcome in diabetic neuropathy. Methods: Forty patients assigned randomly into high tone therapy and conventional therapy groups. Patients assessed by neurophysiological studies for median and sural sensory nerves and activities of daily living assessed by Katz Index of Independence. Results: Neurophysiological measures for median and sural sensory nerves were significantly improved in high tone therapy group but not in conventional therapy group. The function outcome was significantly improved in both groups with the best results for high tone therapy group. Conclusion: High tone therapy was able to improve neurophysiological measures and function outcome in diabetic neuropathy patien