Anaesthesiology is still a young yet growing specialty, especially regarding its long-term effects on the pediatric population and their developing brain. The delayed effects are still under study because potential interventions cannot be studied directly on humans especially on the pediatric population. Anesthesia in newborn infants is sometimes necessary as newborn infants may require surgeries that can not be postponed. Although the development of the brain begins during the last semester of intrauterine life, the brain is not fully developed at birth and continues to grow up to the age of 2 years. It has been studied and widely accepted that the commonly used general anesthetics potentiate inhibitory transmission through gamma-amino-butyric-acid type A (GABAA) receptors and the excitatory transmission is reduced through N-methyl-D-aspartic acid (NMDA) glutamate receptors causing widespread apoptotic neurodegeneration.1 The adverse effect of halothane on the developing brain was reported some two decades ago when it was studied and accepted that long-term exposure to an inhalational agent like halothane, beginning in utero and continuing for several days in the postnatal period, caused impairment of synaptogenesis, reduction in dendritic branching, suppressed axonal growth and reduced myelinated nerves in rodents.