Background: Tuberculosis (TB) is a chronic, progressive mycobacterium infection, often with a period of latency following initial infection. The first line and second line of TB treatment show some of the side effects on the individual. Past studies had shown that second line MDR-TB treatment causes an effect in the auditory domain, but there is a shortage of studies related to drugs used in MDR-TB on speech perception in noise. Objectives: The study aimed to assess the speech perception in noise in individuals with and without tuberculosis. Material and method: A total of 80 participants in the age rane of 20 to 40 years were included in the study. Further, these participants were categorized into two groups. The first group having individuals without tuberculosis while the second group included individuals with tuberculosis. All the participants were initially undergone for basic audiological evaluation followed by Quick Sin test in Kannada. Results and discussion: The results showed that there was a significant difference between the groups on speech perception in noise test. Conclusion: It can be concluded from the current study that individuals with tuberculosis showed poorer performance compared to individuals without tuberculosis on speech perception in noise test.