Background: Hypertrophic scar formation is a major clinical problem in the developing and industrialized worlds, Cryotherapy is the local or general use of low temperatures in medical treatment. Purpose: The purpose of the study was to evaluate the therapeutic effect of cryotherpy in treating hypertrophic scar. Method: Sixty patients who had hypertrophic scar participated in this study. Their ages ranged from 20 to 40 years. The participants were selected from Deraya university outpatient clinic and EL Minia University Hospital. They were randomly distributed into two equal groups. Group A (control group): This group received routine medical treatment and routine physical therapy including (stretching Exercises, Positioning and splinting, Pressure Therapy and Massage). Group B (study group): This group received cryotherapy for 10 minutes at -14 degree, 2 sessions per week, for 10 weeks in addition to routine medical and physical therapy treatment. Measurements were done using MAPS and were recorded in the first visit as a base line and after 3 months of treatment. Results: There was a statistically significant difference between groups in the study group compared with the control group regarding post treatment data of surface, height, thickness, color, pigmentation and the total score of MAPS where p value equals (0.005, 0.0001, 0.0005, 0.0021, 0.00016, < 0.00001) respectively. Conclusion: Cryotherapy had significant effect in improving the outcome and treating hyper trophic scar.