Introduction: Polycystic ovarian syndrome (PCOS) is an endocrine disorder with multiple etiology and affecting women in reproductive age group. It has become a major problem in modern era and requires a multimodality of treatment. Material and methods: The study was conducted on 100 PCOS patients attending PGIMS, Rohtak outpatient department to compare the efficacy of combined oral contraceptives (COCs) and cyperoterone acetate-ethinyl estradiol (CPA-EE) combination on metabolic parameters. This was a prospective interventional study conducted for one and half year. Patients were followed at one, three and six months of treatment and comparison was made from baseline to six months of treatment. Results: Both the drugs did not change the waist circumference and blood pressures of the patients, while improved fasting blood sugars from third month of treatment. COCs were found to deteriorate the sugar levels more significantly when compared to CPAEE. Both the drugs significantly derange the triglyceride and high density lipoprotein levels, CPA-EE being more than COCs