The purpose of this study was to measure certain hematological parameters (Hb, PCV, and WBC counts), as well as the levels of malondialdehyde (MDA), glutathione (GSH), and insulin-like growth factor-1 (IFG-1). The study was carried out on blood samples from patients with thalassemia from the beginning of November 2021 to the end of March 2022. The study employed a total of (45) samples from the city of Tikrit city and (18) samples from a control group of healthy individuals. The age range for both groups was (15–17), The results showed that there were significant increase at (P≤ 0.05) in the levels of (Hb, PCV and WBCs count) in patients group which are (12.66±3.54 a) g/dl, (16.89±4.08 a) , (13.2±3.74 a ) respectively and control group were (8.59±2.84 b) g/dl ,(10.24±3.52 b) and (11.37±3.66 b) respectively ,the results also showed a significance increase (P≤ 0.05) in levels of IGF-1 in patients group which are (7.832±2.33 a) ng/ml and (2.181±0.72 b) ng/ml in control group, the study revealed that there was a significance decrease(P≤ 0.05) in levels of (MDA and GSH) in patients group which are (1.203±0.32 b)m mol/L ,( (0.0186±0.007 b)m mol/L and (2.671±0. 512 a) m mol/L and (0.0402±0.010 a) m mol/L in control group respectively.