Online ISSN: 2515-8260

EFFECT OF ARECA CATECHU EXTRACT ON MAXIMAL ELECTROCONVULSIVE SHOCK INDUCED SEIZURE IN RATS WITH SPECIAL EMPHASIS ON OXIDATIVE STRESS AND HISTOLOGICAL CHANGES IN THE BRAIN

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Sukesh Bhat, 1Thirunavukkarasu, 2*Eesha B R, 3 SenthilkumarSivanesan4,5

Abstract

In this study, we looked at the antiepileptic properties of an Areca catechu fruit hydroalcoholic extract in electrically induced seizures in Wistar albino rats, with a focus on oxidative stress and histopathological changes in different areas of the brain. The hydroalcoholic extract of Areca catechu fruit (1g/kg) and (2 g/kg) were tested for antiepileptic activity in Wistar albino rats during a maximal electroconvulsive shock-induced seizure using an electroconvulsiometer. The hydroalcoholic extract of Areca catechu significantly decreased the tonic hind limb extension (THLE) duration and protected rats from the seizures induced by maximal electroconvulsive shock. The study concluded that an alcoholic extract of the Areca catechu fruit has antiepileptic properties because it shortens the duration of the extensor phase of seizures.

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