The delivery of the infant into the hands of a conscious and pain free mother is one of the utmost exciting and satisfying moments in medicine Opioids, although useful as adjuvants, are linked with detrimental side effects. Hereafter crucial adjuvants that can be used with bupivacaine for stable intraoperative circumstances and extending the postoperative analgesia with minimized side effects are being the objective from long back. The p r es ent study was aimed to evaluate and compare the scope of d es i r a b le analgesic efficacy by injecting bupivacaine alone and in combination with dexmedetomidine, clonidine, and neostigmine intrathecally in elective lower abdominal cesarean section, over the early postoperative hours, in a randomized, double-blind comparative study