Background: Cardiovascular disease in patients with breast cancer undergoing chemotherapy is of major growing concern. The commonly used chemotherapeutic regimen have cardiotoxic effects including doxorubicin, trastuzumab and other agents .these have acute effects on cardiac function and longterm effects on cardiac remodelling and function. There have been a few studies on this regard, Hence we aimed to investigate the early effects of chemotherapy on cardiac function in addition to association of N – terminal pro-brain natriuretic peptide and echocardiagraphic indices.