Before 8 months nobody was aware about the corona virus (COVID-19) and now this virus has reached in almost all countries, infecting 86,162,875 peoples with 1,861,846 deaths.(as on 05th January 2021 ,09:08 GMT ,Source-Worldometer information).Almost all countries are trying to make vaccine against corona virus but yet all are in developing stage. Now COVID -19 pandemic has reached a dangerous phase of second wave which is imposing the relock down worldwide. The economy of all entire countries has facing a huge slow down, suddenly falling stock markets, moving restrictions, lack of supply, unemployment are the major challenges worldwide. The healthcare systems of countries across the world are collapse due to the pandemic. Due to the fear of getting infected from corona virus and to maintain the physical distancing most of peoples are moving towards online purchasing during the lockdown period. Purchasing of the medicines through the digital platform is also not exemption for it due to ease of access in one click with safety during COVID-19 pandemic. E- Pharmacies with existing pharmacies have played the important role to help the nation in COVID -19 pandemic fight for 24 × 7.This research paper focuses on COVID-19and E-Pharmacy from different dimensions.