Abstract. The scientific work presents the results of dynamic research to study the structure, level and dynamics of the general, professionally conditioned and professional morbidity of employees of SE “Ferghana Oil Refinery”, SE “Ferghana Heat and Power Plant” and JSC “Ferghanaazot”, which are part of the Kyrgyz Industrial Zone of the Ferghana region for 5 years (2010-2014). The main professional qualification groups working at the enterprises under research at the age of 19 to 40 years with the work experience from 1 to 20 years were surveyed. 6000 man-days of working observations were made. High morbidity rates were revealed among the employees of Ferghana Oil Refinery and JSC “Ferghanaazot” in the groups with the experience of up to 5 years and 11-20 years. The analysis of morbidity rate among age groups of workers showed high indices at the age above 35 years. In the structure of morbidity for the period of 2010-2014, the first leading places were occupied by diseases of respiratory organs, then by diseases of circulatory and digestive organs, traumas and poisoning, then by diseases of the nervous system, skin and subcutaneous tissue. High respiratory diseases are associated with long-term exposure to occupational risk factors, where chemical contamination is the most dangerous.