Drug-induced gingival over growth is a condition caused by undesired effects due to the intake of certain drugs. The most commonly involved drugs are anti-convulsants, calcium channel blockers and immunosuppressants. Understanding the patho-physiological changes and reaction of gingival fibroblasts is more important however an exact pathological explanation is still not completely understood in many cases. Genetic predisposition and oral hygiene plays a major role in DIGO. The management of DIGO includes ruling out the causative agent and proper assesment of the gingival tissue, and an effective treatment which differs to each individual is established.