Gilo (Tinospora cordifolia) is a plant medicine which is widely used in Unani system of medicine (USM) for various therapeutic purposes. It has antipyretic, analgesic, anti- inflammatory purpose and antidiabetic potential. This is a review paper based on published literature which discusses morphology, habitat, pharmacological actions and ethno-botanical therapeutic uses of this medicinal plants. It is concluded that, this is one of the best herbal medicine for pyrexia, diabetes mellitus and syphilis in USM.