ABSTRACT: Forensic odontology is a branch of forensic science that is capable of human identification through dental tissues or more precisely teeth in cases where there is the destruction of body tissues in criminal investigations and mass disasters. Forensic odontology mainly involves dentists collaborating in legal and criminal issues. Parameters like age and gender identification are crucial in identifying the victim or victims. Through the past two decades, the molecular aspect of forensic sciences has expanded considerably, Molecular advancements in science like DNA analysis have expanded the reach of forensic dentistry, since teeth possess the ability to resist extreme environmental condition be it temperature, pressure or any chemical aggressions. Teeth are found to be the abundant supply for DNA, and hence it is an excellent source of genomic DNA. The present review focuses on molecular advancements in the field of forensic odontology as DNA analysis advances as molecular signature in forensic odontology.