Computer engineered complete dentures (CECDs) or digital dentures have been increasingly being fabricated by dentists these days. Enhanced clinical outcomes are only one of the many benefits of computer-aided design and computer-aided manufacturing (CAD-CAM) technology's introduction to clinical and dental laboratory procedures. The objective of this systematic review was to compare and summarise the findings of clinical research pertaining to CD manufacture in terms of the distinctions between CAD-CAM technology and traditional approaches. Medline/PubMed, Cochrane Library, SciELO, Web of Science, and Embase were the databases searched for this systematic review was conducted in accordance with the criteria established by the Cochrane Collaboration and in accordance with the Preferred Reporting Items for Systematic Reviews and MetaAnalyses, PRISMA 2020 guidelines. Based on the results of this systematic review, conclusions were drawn and presented.