: insecticide chlorpyrifos Mg/Fe –LDHs was prepared by indirect and direct ion exchange. description of this compound Mg/Fe–LDHs and hybrid nanocompound done by FT –IR spectrophotometer before and after intercalation formation of hybrid nano compound , then cooperation to ensure the form hybrid nanocompound and the two and three dimensional image of the above compound in (AFM) for the layer and hybridnanocompound. The aim of this study is the synthesis hybrid nanocompounds for limited of environment pollution and study the effect of diffusion rate caused by insecticide chlorpyrifos released from the hybrid nanocompound layers by the diffusion rate anion that effect on kinetics of different aqueous solution. The results study of effect all aqueous solution on diffusion rate anionin same time fromhybrid nanocompound layer, appeared that thediffusion rate of hybrids to liquids in different carbonate, phosphate and sulfate concentration0.5Mthe diffusion rate release in to aqueous solution carbonate>phosphate>sulfate. The results of the study number of active sites of hybrid nanocompound in the aqueous and alcoholic medium by direct and indirect ion exchange process showed that is better for preparation in alcoholic medium and that the number active sites is higher in hybrid nano compound prepared by indirect ion exchange fromprepared by direct ion exchange.