Abstract: Covid -19 has mild symptoms which is like Common Cold and severe symptoms that same as like SARS and MERS. Common Cold itself has the main symptoms of fever, cough, myalgia, headache, nasal congestion, and sore throat. Because of this, many people are mistaken about the symptoms caused by Covid-19 and Common Cold. The aim of this research is to find out the different symptoms of Covid-19 and Common Cold. This study uses a method with literature review. Sources from the research were obtained by searching for national and international journals. Generally journals are indexed on Google Scholar, Elsevier, Science Direct, e-books, and others. Literature collected in accordance with the theme to be raised. This study shows the symptoms of Covid-19 and Common Cold have similarities, because both are diseases that attack the upper respiratory system. But Covid19 symptoms themselves are moderate to severe and can be accompanied by shortness of breath, so it can causes ARDS (Acute Respiratory Disease Syndrome) which can lead to death. The laboratory test is a way to make a diagnosis to make sure the symptoms are caused by Covid-19 which is tested by reverse-transcription-polymerase-chain-reaction (RT-PCR) which results are positive on Covid-19. As for the Common Cold laboratory tests themselves are not required. The symptoms of Covid-19 and Common Cold have a similarity, because both are diseases that attack the upper respiratory system. Covid-19 can be enforced by laboratory testing while the Common Cold is not needed.