Background: Terminal disease causes pain that is unbearable by the patient. Euthanasia is an act of someone ending his life in order to relieve the pain he is suffering. Euthanasia is still prohibited in Indonesia. Education on ethical and basic knowledge between junior high schools located on the banks of the Martapura river may have differences due to local traditions regarding euthanasia, therefore research is needed to see differences in knowledge, attitudes and perceptions about euthanasia among SMPN 1 Astambul and SMPN 1 Karang Intan students. Methods: The research design used analytic observational with cross sectional method. The sample consisted of 100 students, the data were analyzed using the chi-square test with a 95% degree of confidence. Result: The results showed that the level of students' knowledge about euthanasia was still lacking, the majority of attitudes and perceptions about euthanasia were negative. Conclusion: There were no significant differences in knowledge, attitudes, perception regarding euthanasia based on their origin school. There were a significant differences in knowledge and attitudes based on parental education and occupation.